About CD138 / Syndecan 1 monoclonal antibody

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References *Kuchen S, Robbins R, Sims GP, Sheng C, Phillips TM, Lipsky PE, Ettinger R: Essential role of IL-21 in B cell activation, expansion, and plasma cell_x000D_ generation during CD4+ T cell-B cell collaboration. J Immunol. 2007 Nov 1;179(9):5886-96._x000D_ _x000D_ _x000D_ , *Cheriyath V, Glaser KB, Waring JF, Baz R, Hussein MA, Borden EC: G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells. J Clin Invest. 2007 Oct;117(10):3107-17._x000D_ _x000D_ _x000D_ , *Yang Y, MacLeod V, Dai Y, Khotskaya-Sample Y, Shriver Z, Venkataraman G, Sasisekharan R, Naggi A, Torri G, Casu B, Vlodavsky I, Suva LJ, Epstein J, Yaccoby S, Shaughnessy JD Jr, Barlogie B, Sanderson RD: The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy. Blood. 2007 Sep 15;110(6):2041-8._x000D_ _x000D_
Background CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis. _x000D_
Shipping and storage Mouse Monoclonal Antibody against Human CD138 / Syndecan 1, Clone: B-A38 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
About Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
Specificity The antibody B-A38 recognizes CD138 (syndecan 1), a 65-70 kDa heparan sulfate proteoglycan expressed mainly in the epidermis and plasma cells, but also in growth factor-stimulated lymphocytes. _x000D_
Negative species reactivity at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
Properties If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Storage buffer The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
Long name Mouse Monoclonal Antibody against Human CD138 / Syndecan 1, Clone: B-A38
Immunogen U266 human peripheral blood myeloma cell line
Purification method Purified by affinity chromatography
Research area CD and Related Antigens (Human)
Clonality Monoclonal Antibody (Mab)
Species reactivity Human (Homo sapiens)
Purity > 95% (by SDS-PAGE)
Format/conjugation Pacific Orange
French translation anticorps
Applications FC, IHC
Antigen CD138
Clone B-A38