The best Syndecan - 4 (Human) ELISA kit, Syndecan antibody, Syndecan 1 Antibody ALEXA FLUOR 555 products, quick delivery, high quality.
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|References||*Jourdan M, Caraux A, Caron G, Robert N, Fiol G, Rème T, Bolloré K, Vendrell JP, Le Gallou S, Mourcin F, De Vos J, Kassambara A, Duperray C, Hose D, Fest T, Tarte K, Klein B: _x000D_ Characterization of a transitional preplasmablast population in the process of human B cell to plasma cell differentiation. _x000D_ J Immunol. 2011 Oct 15;187(8):3931-41., *Nadalin MR, Fregnani ER, Silva-Sousa YT, Perez DE: Syndecan-1 (CD138) and Ki-67 expression in odontogenic cystic lesions. Braz Dent J. 2011;22(3):223-9., *Noll JE, Vandyke K, Hewett DR, Mrozik KM, Bala RJ, Williams SA, Kok CH, Zannettino AC: PTTG1 expression is associated with hyperproliferative disease and poor prognosis in multiple myeloma. J Hematol Oncol. 2015 Oct 6;8:106., *Atanackovic D, Hildebrandt Y, Templin J, Cao Y, Keller C, Panse J, Meyer S, Reinhard H, Bartels K, Lajmi N, Sezer O, Zander AR, Marx AH, Uhlig R, Zustin J, Bokemeyer C, Kröger N: Role of interleukin 16 in multiple myeloma. J Natl Cancer Inst. 2012 Jul 3;104(13):1005-20., *Krishnan SR, Luk F, Brown RD, Suen H, Kwan Y, Bebawy M: Isolation of Human CD138(+) Microparticles from the Plasma of Patients with Multiple Myeloma. Neoplasia. 2016 Jan;18(1):25-32., *Gattei V, Godeas C, Degan M, Rossi FM, Aldinucci D, Pinto A: Characterization of anti-CD138 monoclonal antibodies as tools for investigating the molecular polymorphism of syndecan-1 in human lymphoma cells. Br J Haematol. 1999 Jan;104(1):152-62.|
|Background||CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis. _x000D_|
|Shipping and storage||Mouse Monoclonal Antibody against Human CD138 / Syndecan 1, Clone: MI15 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.|
|About||Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.|
|Specificity||The mouse monoclonal antibody MI15 recognizes CD138 (syndecan 1), a 65-70 kDa heparan sulfate proteoglycan expressed mainly in the epidermis and plasma cells, but also in growth factor-stimulated lymphocytes.|
|Negative species reactivity||at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity|
|Properties||If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.|
|Purification method||Purified from hybridoma culture supernatant by protein-A affinity chromatography.|
|Long name||Mouse Monoclonal Antibody against Human CD138 / Syndecan 1, Clone: MI15|
|Storage buffer||Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4|
|Species reactivity||Human (Homo sapiens), Non-Human (Homo sapiens) Primates, Rat|
|Immunogen||A mixture of U266 and XG-1 human myeloma cell lines|
|Research area||CD and Related Antigens (Human)|
|Clonality||Monoclonal Antibody (Mab)|
|Purity||> 95% (by SDS-PAGE)|
|Applications||FC, IP, WB, IHC(P)|