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The best quality, top Anti - SDCBP Antibody, Anti - Syndecan 4 (SDC4) Antibody, Recombinant Human Syndecan - 4 products prices, the best delivery.
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0.1mg
R30996
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| Detail | Description |
|---|---|
| Description | Syndecan-2, also known as SYND2, HSPG1, HSPG, and Fibroglycan, is a protein that in humans is encoded by the SDC2 gene. The protein encoded by this gene is a transmembrane(type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. By Southern hybridization to a panel of human-mouse somatic cell hybrid DNA and by in situ hybridization, Marynen et al.(1989) showed that the heparan sulfate proteoglycan core protein maps to 8q22-q24.(Heparan sulfate proteoglycan of basement membrane appears to be encoded by a gene on human chromosome 1.Bobardt et al.(2003) demonstrated that syndecans, including SDC2, can function as in trans HIV receptors via binding of HIV-1 gp120 to the syndecan heparan sulfate chains. Flow cytometric analysis demonstrated SDC expression on endothelial cells. HIV bound to SDC on endothelial cell lines maintained its infectivity for at least 1 week, compared with less than 1 day for unbound virus. Bobardt et al.(2003) suggested that SDC-rich endothelial cells lining the vasculature can provide a microenvironment that boosts HIV replication in T cells. |
| Storage | After reconstitution, the Syndecan 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing. |
| Notes | The stated application concentrations are suggested starting amounts. Titration of the Syndecan 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Species reactivity | Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur. |
| Immunogen | An amino acid sequence from the middle region of human Syndecan 2/HSPG (EETDKEKVHLSDSERKMD) was used as the immunogen for this Syndecan 2 antibody. |
| Properties | If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. |
| Intented use | This Syndecan 2 antibodyis to be used only for research purposes and not for diagnostics.. |
| Recommended dilutions | Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml,IHC (Frozen): 0.5-1ug/ml |
| Concentration | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Host animal | Rabbit (Oryctolagus cuniculus) |
| Clonality | Polyclonal (rabbit origin) |
| Form | Antigen affinity purified |
| Clone | Polyclonal antibody |
| Recognised antigen | Syndecan 2 (HSPG) |
| Tested applications | WB, IHC-P, IHC-F |
| Purity | Antigen affinity |
| Conjugation | Unconjugated |
| French translation | anticorps |
| Category | Antibody |
| Uniprot # | P34741 |