About Recombinant Human Syndecan-1 / SDC1 / CD138 Protein (His tag) 100µg

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Size

100µg

Catalog no

PKSH031123-100µg

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Details

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DetailDescription
BackgroundSyndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.
PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin<1.0 EU per µg as determined by the LAL method
ReconstitutionPlease refer to it for detailed information.
FormulationLyophilized from sterile PBS, pH 7.4
SynonymCD138;SDC;SYND1;syndecan;Syndecan-1
Purity>92 % as determined by SDS-PAGE
SourceRecombinants or rec. proteins
SequenceMet 1-Glu 251
Expressed HostHEK293 Cells
Grouprecombinants
AccessionNP_002988.3
AP Mol Mass48-55 kDa
Conjugationhistidine
Mol Mass25.6 kDa
Fusion tagC-His
ActivityNA