About Recombinant Mouse Syndecan-1 / SDC1 / CD138 Protein (His tag)

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Size

50µg

Catalog no

PKSM040569-50µg

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Details

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DetailDescription
BackgroundSyndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.
TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin<1.0 EU per μg of the protein as determined by the LAL method
SynonymAA408134;AA409076;CD138;Sstn;syn-1;Synd;Synd1
FormulationLyophilized from sterile PBS, pH 7.4
Purity> 80 % as determined by SDS-PAGE
SourceRecombinants or rec. proteins
SequenceMet 1-Glu 252
Expressed HostHEK293 Cells
Latin nameMus musculus
Grouprecombinants
AccessionNP_035649.1
AP Mol Mass45-60 kDa
Conjugationhistidine
Mol Mass26 kDa
Fusion tagC-His
ActivityNA