About Recombinant Rat Syndecan-1 / SDC1 / CD138 Protein (His tag) 100µg

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Size

100µg

Catalog no

PKSR030215-100µg

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Details

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DetailDescription
BackgroundSyndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.
AboutRats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Endotoxin<1.0 EU per μg of the protein as determined by the LAL method
FormulationLyophilized from sterile PBS, pH 7.4
Purity(76+20) % as determined by SDS-PAGE
SourceRecombinants or rec. proteins
Latin nameRattus norvegicus
AP Mol Mass47 and 49 KDa
Grouprecombinants
ExpressedHostHEK293 Cells
SequenceMet1-Lys253
SynonymSDC1;Synd1
Conjugationhistidine
Mol Mass25.6 kDa
AccessionP26260
Fusion tagC-His
ActivityNA